Curr Protoc Neurosci. 2003 Nov;Chapter 9:Unit 9.17.
Measurement of panic-like responses following intravenous infusion of sodium lactate in panic-prone rats.
Sajdyk TJ, Keim SR, Thielen SR, Fitz SD, Shekhar A.
Indiana University Medical Center, Indianapolis, Indiana, USA.
This unit describes a putative animal model for panic disorder. The basic premise is that pharmacological disruption of critical brain regions implicated in the circuitry of anxiety will lead to a condition similar to that of the human disorder. A clinically relevant test, the sodium lactate challenge, is utilized to assess parallels between the human condition and this rat model.
PMID: 18428590 [PubMed - indexed for MEDLINE]
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